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FECVFeline Enteric Coronavirus
FECVForests with Exceptional Conservation Value
FECVFabrication Édition Communication Vidéotex (French: Manufacturing Videotex Communication Edition)
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Examination results of the entire portion of spike sequenced in this study indicate that the conserved R-R-S/A-R-R-S motif in FECV is present within a region of the spike gene that shows a high degree of variability, in contrast to other neighboring regions that are more highly conserved (online Technical Appendix Figure 1).
In samples from both cats, the S1/S2 sites had a core sequence R-R-S-R-R-S consistent with the FECV consensus.
Our sequence data show that serotype 1 FECV from feces of asymptomatic cats contain a highly conserved furin cleavage motif at the S1/S2 site, with the following narrow range of residues: [(R [much less than] K/G).
To establish a consistent cause for a virulence shift in FCoV, specifically the predominant serotype I FCoV, we sequenced the entire genome of several FECV and FIPV specimens and then concentrated on the most conspicuous region of consistent difference by collecting and sequencing additional FECV and FIPV samples.
FECV strain RM and FECV strain UCD (FECV UU2) were propagated in specific pathogen-free cats.
To identify key differences between FIPV and FECV, we analyzed their genomes and proteomes; for each nucleotide or amino acid position, we determined the rate at which FIPVs differed from all FECVs at that position.
When compared by phylogenetic analysis, the nucleotide sequences of FIPV and FECV M genes distributed into paraphyletic patterns rather than in monophyletic clusters (Figure, panel A).
FECV 586 and FIPVs 584 and 585 from cattery A; FECV 620 and FIPVs 615 and 622 from cattery G; FECV 10 and FIPV 8 from cattery F).
An alignment of the relevant part of the polypeptide sequence, comprising the presumed signature residues at positions 108, 120, 138, 163 and 199, is shown in the Figure, panel B, for all FIPV and FECV genomes sequenced in this study.
We developed a study of naturally occurring FECV and FIPV using molecular genetic tools by collecting samples from field cases of FIP (cases) and FECV-positive but asymptomatic cats (controls).
One cat (Fca4561) was IHC positive only in the jejunum and negative by histopathologic analysis on all tissues, therefore it was classified as FECV asymptomatic.
First, gene sequences from healthy cats infected with FECV displayed a monophyletic cluster pattern that was generally distinctive from cats diagnosed with FIP in the membrane, NSP 7b, and spike-NSP3 gene segments (Figure 4).