FEPSPField Excitatory Post-Synaptic Potentials
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Bath application of asiatic acid affected the amplitudes of the fEPSPs evoked in a concentration-dependent manner in slices from 1, 3, 10, 30 and 100 [micro]M asiatic acid.
In contrast to the effect of atropine, the TDE-induced reduction in Schaffer collateral fEPSPs persisted despite pretreatment of the slices with pancuronium bromide (100 [micro]M).
The TDE effect of fEPSPs that we observed in CA1 was similar to the effect of galanthamine, a reversible AChE-I, and of ACh.
The ACh effect in suppressing fEPSPs was also completely blocked by 10 atropine (Fig.