FETAX

AcronymDefinition
FETAXFrog Embryo Teratogenesis Assay-Xenopus
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One treatment was a control with FETAX solution, a second treatment was acetaminophen (160mg/L), and three concentrations of caffeine were (10, 75, 150) tested with and without acetaminophen.
Place embryos in fresh dejellying solution (100 mL, 2% L-cysteine [Sigma C-7352] in FETAX solution, pH to 8) and swirl until the jelly coat is removed (~2 minutes; Figure 2B).
Sort the eggs in a two-stage procedure by placing them in 100-mm glass Petri dishes with FETAX solution (Figure 3A).
The embryos (320) that were selected were divided into groups of 20 and placed into 16 petri dishes with 8 ml of a FETAX test solution.
The FETAX assays will be carried out with the jelly coats removed.
In addition, the CMC concentration of HA is near the LC50 as determined by FETAX tests.
MONSANTO SITE EXAMINED BY USE OF THE FETAX ASSAY AND DEVELOPMENT OF ADDITIONAL DEVELOPMENTAL TOXICITY ASSAYS.
FETAX has been used with an exogenous metabolic activation system to identify chemicals that are pro-teratogens or chemicals inactivated by cytochrome P-450 (Fort et al.
FETAX is a 96-hour developmental toxicity assay that screens for direct acting teratogens.
We analyzed water samples and aqueous sediment extracts from three PCB-contaminated study sites ranging from 1 - 30 km from the Monsanto plant using the FETAX developmental toxicity assay.
In order to assess the potential effects of these pollutants on aquatic animals under controlled laboratory conditions, we analyzed water and sediment extracts from five sites on Snow and Choccolocco Creeks and Logan Martin Lake by the FETAX developmental toxicity assay, a standardized toxicity assay using early Xenopus embryos.
The purpose of this research was to determine how well FETAX could predict the known mammalian developmental toxicity of meclizine.