Experimental models FFR, SHR, and FFHR showed cardiac remodeling, which decreased, after chronic treatment with L, in the experimental groups studied but only the FFHR group showed statistically significance.
In experimental models FFR, and FFHR a significant reduction of the media/lumen ratio was observed, demonstrating the presence of eutrophic remodeling of the mesenteric arteries studied.
At the systemic level, C-reactive protein (hsCRP) was evaluated; it showed significant differences among FFR and FFHR models, demonstrating the presence of inflammation in these groups.
In experimental models FFR, FFHR, and SHR the expression of these markers increased.
Model FFHR presents an important expression of NF-[kappa]B in the entire vascular wall (intima, media, and adventitia) as well as endothelial expression of VCAM-1, while in other models both markers were present only in the endothelium.
In models FFR and SHR the activity and the expression of these MMPs increased moderately, while the FFHR model presents maximum activity and expression of both collagenases (Figure 2).
We demonstrate that chronic treatment with L did not modify the metabolic variables associated with metabolic syndrome of models FFHR and FFR.
Both vascular and cardiac remodeling showed significant differences after treatment with L, mainly in the FFHR model.