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However, there are no studies of b-FGF concentrations in BMAC; in one study, FGF-1 was not detected in BMAC or PRP , but b-FGF was not evaluated.
Detection of BMP-2, VEGF, FGF-1, IL-1[alpha], and IL-1[beta] in Equine PRP.
ELISA Assays for Growth Factors BMP-2, VEGF, and FGF-1 and Proinflammatory Cytokines IL-1a and IL-1[beta].
Caption: FIGURE 8: The concentration of growth factors (a) BMP-2, (b) VEGF, and (c) FGF-1 in PRP incubated with different concentrations of AuNPs; * p < 0.05 and ** p < 0.01.
The team began testing FGF-1 on humans 3 years ago.
Angiography revealed that every patient who got active FGF-1 showed signs of blood vessel regeneration near the injection, allowing blood to bypass the second blockage, the researchers report in the Feb.
To date, the patients who got injections of active FGF-1 have shown no side effects.
"The application of an angiogenic growth factor like FGF-1 is not able to replace bypass surgery.
CVBT intends to use the data, in conjunction with CVBT's own data, to apply to the US Food and Drug Administration (FDA) to advance its FGF-1 diabetic wound healing drug candidate, CVBT-141B, to a pivotal Phase III trial, which, if approved by the FDA, is anticipated to commence in 2011.
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- FGF receptor
- FGF-inducible kinase