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* Currently Available GF Bioassays Service: sh-Polypeptide-l(FGF2), -3(FGF7), -4(SCF), -7(hGH), -9(VEGF), -10(FGF10), -11(FGF1), -28(PRL), -40(hPL), -71 (VIP), -78(HSP90A), sh-Oligopeptide-1(EGF), -4(TMS)
A functional polymorphism at the FGF10 gene is associated with extreme myopia.
The Erbin, Msrb2, Ptf1a, and Fgf10 genes were closely linked with the top 3 SNPs of FCR (Table 5).
For example, in the extracellular space, glycyrrhizin modulated NF-[kappa]B activity by regulating interleukin 4 (IL4), 1L23A, and fibroblast growth factor 10 (FGF10) genes (Fig.
Dado que el LPH aislado, es una alteracion congenita compleja de origen multifactorial, en la mayoria de los casos, esta causado por la interaccion entre el medio ambiente y varios genes involucrados con la via de senalizacion FGF, incluyendo FGFR1, FGFR2, y FGFR 3, FGF2, FGF3, FGF4, FGF7, FGF8, FGF9, FGF10 y FGF18, NUDT6, FCTBR, y PAX38, entre otros que podrian estar relacionados con esta via de senalizacion.
Local growth factors such as IGF-I, EGF and fibroblast growth factor 10 (FGF10) added into the maturation medium improves the oocyte maturation, resulting in an increase in the in vitro blastocyst rate (WANG et al., 2009; ZHANG et al., 2010).
DE was cultured for 3 days with RPMI medium containing 2% FBS and supplemented with FGF10 (50 ng/mL) and KAAD-cyclopamine (CYC) (20 ng/mL).
Also showing significant associations with ovarian cancer were variants in 6 other genes, including FGFR1, FGFR2, FGF7, FGF9 (fibroblast growth factor 9), FGF10 (fibroblast growth factor 10), and FGF14.
Both FGF10 signaling and Pax6 play important roles in lacrimal gland formation [13, 15].
Null mutants for Fgf10 mostly lack prostate budding , while conditional deletion of FGFR2 or Frs2[alpha], a downstream signaling component in prostate epithelium, results in defects in branching morphogenesis [207, 208] It has been also demonstrated that ERK 1/2 is rapidly activated in the urogenital sinus (UGS) when induced by FGF10, and the inhibition of FGFR activity mostly inactivates phosphorylated ERK 1/2 in the UGS, suggesting that FGF10 may signal through MAPK pathway .
Fgf3 is expressed solely in the mesenchyme, while Fgf4, Fgf8, and Fgf10 are expressed by the epithelium.
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- FGF receptor
- FGF-inducible kinase