* Currently Available GF Bioassays Service: sh-Polypeptide-l(FGF2), -3(FGF7), -4(SCF), -7(hGH), -9(VEGF), -10(
FGF10), -11(FGF1), -28(PRL), -40(hPL), -71 (VIP), -78(HSP90A), sh-Oligopeptide-1(EGF), -4(TMS)
A functional polymorphism at the
FGF10 gene is associated with extreme myopia.
The Erbin, Msrb2, Ptf1a, and
Fgf10 genes were closely linked with the top 3 SNPs of FCR (Table 5).
For example, in the extracellular space, glycyrrhizin modulated NF-[kappa]B activity by regulating interleukin 4 (IL4), 1L23A, and fibroblast growth factor 10 (
FGF10) genes (Fig.
Dado que el LPH aislado, es una alteracion congenita compleja de origen multifactorial, en la mayoria de los casos, esta causado por la interaccion entre el medio ambiente y varios genes involucrados con la via de senalizacion FGF, incluyendo FGFR1, FGFR2, y FGFR 3, FGF2, FGF3, FGF4, FGF7, FGF8, FGF9,
FGF10 y FGF18, NUDT6, FCTBR, y PAX38, entre otros que podrian estar relacionados con esta via de senalizacion.
Local growth factors such as IGF-I, EGF and fibroblast growth factor 10 (
FGF10) added into the maturation medium improves the oocyte maturation, resulting in an increase in the in vitro blastocyst rate (WANG et al., 2009; ZHANG et al., 2010).
DE was cultured for 3 days with RPMI medium containing 2% FBS and supplemented with
FGF10 (50 ng/mL) and KAAD-cyclopamine (CYC) (20 ng/mL).
Also showing significant associations with ovarian cancer were variants in 6 other genes, including FGFR1, FGFR2, FGF7, FGF9 (fibroblast growth factor 9),
FGF10 (fibroblast growth factor 10), and FGF14.
Both
FGF10 signaling and Pax6 play important roles in lacrimal gland formation [13, 15].
Null mutants for
Fgf10 mostly lack prostate budding [206], while conditional deletion of FGFR2 or Frs2[alpha], a downstream signaling component in prostate epithelium, results in defects in branching morphogenesis [207, 208] It has been also demonstrated that ERK 1/2 is rapidly activated in the urogenital sinus (UGS) when induced by
FGF10, and the inhibition of FGFR activity mostly inactivates phosphorylated ERK 1/2 in the UGS, suggesting that
FGF10 may signal through MAPK pathway [209].
Fgf3 is expressed solely in the mesenchyme, while Fgf4, Fgf8, and
Fgf10 are expressed by the epithelium.