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* Lipid Bilayer-based Carriers loaded with Polypeptide Growth Factors: sh-Oligopeptide-1 (EGF), -4(Thymosin-b4); sh-Polypeptide-1 (FGF2), -3(FGF7), -4(SCF), -5(TGFb3), -7(hGH), -9(VEGF), -10(FGF10), -11(FGFl), -15(TIMP2), -22(TGFbl), -28(PRL), -40(hPL), -59(PDGF), -71 (VIP), -78(HSP90A), -93(CTGF), -101 (Adiponectin)
Also showing significant associations with ovarian cancer were variants in 6 other genes, including FGFR1, FGFR2, FGF7, FGF9 (fibroblast growth factor 9), FGF10 (fibroblast growth factor 10), and FGF14.
The consistent amount of NRP1 protein in undifferentiated ASCs (see Figure 8(b)) and its further increase in the first days of adipogenesis (see Figure 10) support our hypothesis that NRP1 might mediate FGF7 activities during clonal expansion of ASCs, while FGFR2-IIIb mediates FGF7 action subsequently (maybe in association with NRP1 as a coreceptor).
The presented data indicate that, among others, the activation takes place due to the opposed expression profile of genes and their regulating microRNAs at the site of inflammation (Figure 6); while the expression of all tested mesenchymal markers (Egr1, Fgf2, Fgf7, Jak2, Notch2, Hif1a, Zeb2, Mmp9, Lox, and Vim) was significantly induced, microRNAs regulating their expression decreased (miR-192, miR-143, miR-375, miR-30a, miR-107, miR200b, and miR-125a).
For the low-expressed FGF7 gene, the majority of the overall noise was introduced at the RT step.
In particular, this is illustrated by significant differences in genes related to neoangiogenesis and tissue remodeling (such as Ccl2, Hif1[alpha], Fgf7, and Igf) (Figures 1(a) and 1(b)).
Estrogen also regulates expression of many uterine endometrial genes, including fibroblast growth factor 7 (FGF7), lysophosphatidic acid receptor 3 (LPAR3), and secreted phosphoprotein 1 (SPP1) during the implantation period (Jaeger et al., 2001).
In addition, MSCs reduced alveolar bacterial counts and improved alveolar macrophage phagocytosis after direct bacterial injury mediated by FGF7, LL-37 [35, 36].
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- FGF-inducible kinase
- FGFR signalling adaptor
- FGFR substrate 2
- FGFR-signalling adaptor SNT