ADSC, FGSC, and ovary cell suspension groups euthanized on day 7 after transplantation had a significant improvement compared to control.
Although ADSC transplantation has shown an improvement in viable follicles, in this study, FGSC transplantation showed better results on days 7 and 14 of euthanasia.
For example, with assisted reproductive technologies involving cryopreservation of ovarian cortical tissue already in development for female cancer patients [28, 29] isolation and expansion of FGSC from this tissue, before or after cryopreservation, might be useful for new fertility applications.
Our findings in this study suggest potential therapeutic effects for ovarian dysfunction by intraovarian injection of ADCs and FGSC. And the transplant of those cells may have a role in restoring damaged ovarian tissue induced by cisplatin.
Furthermore, the results obtained specifically with FGSC therapy suggested that the ovarian stem cells should be a candidate for future ovarian failure restoration because it provides a better clinical outcome, probably considering it a committed stem cell with the ovarian microenvironment offering it a higher capability to specifically enhance ovarian tissue repair.