Another study of 23 primary UMs examined CpG promoter methylation of several cancer-related genes including p16INK4a , Tissue inhibitor of metalloproteinases 3 ( TIMP3 ), RASSF1 , RARB , FHIT
, hTERT , and APC .
Meanwhile, correlated with clinical parameters, promoter hypermethylation and expression loss of PARK-2, RAR[beta], and FHIT
are significantly higher in cervical cancer than in CINs and normal tissues, resulting in a significant association with tumor stage and histological grade [46, 47].
Perfil de metilacion de genes supresores de tumores APAF, ASSP1, p73, FHIT
en pacientes con leucemia linfoblastica aguda infantil.
Keywords: Hepatocellular carcinoma, Fragile histidine triad, FHIT
, Proteomics, Bioinformatics.
Quantitative detection of methylation of FHIT
and BRCA1 promoters in the serum of ductal breast cancer patients.
Weinstein, "Characterization of PKCI and comparative studies with FHIT
, related members of the HIT protein family," Experimental Cell Research, vol.
reconfirmed BRCA1 was not significantly methylated in breast cancer serum samples; however, hypermethylation of the FHIT
was significantly higher in individuals with breast ductal carcinoma compared to healthy controls and those with benign breast tumours .
Viral integrants were detected into or close to various cellular genes that have been previously identified and novel ones including DLG2, FHIT
, HMGA2, KLF5, KLF12, LRP1B, LEPREL1, MYC, and SEMA3D genes .
Frequent hypermethylation of DAPK, RARbeta, MGMT, RASSF1A and FHIT
in laryngeal squamous cell carcinomas and adjacent normal mucosa.
Algunos de los genes estudiados en el contexto de hipermetilacion de sus promotores en cancer de pulmon incluyen: CDKNA/P16INK4a, RASSF1, MGMT, APC, DAPK, FHIT
, CDH13, RAR [beta], SHOX2, RUNX3, CDH1, TSCL1, ASC/TMS1, DAL1, PTEN, GSTP1.
(61) Other genes that have been found to be hypermethylated in multiple studies of smoking-related cancers include TIMP3, FHIT
, RUNX3, MLH1, and CHFR.
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