In the 14-3-3 FKO mice, there is a significant reduction of the NMDA receptor-mediated synaptic currents in CA1 pyramidal neurons which express the 14-3-3 inhibitor.
In 14-3-3 FKO mice, expression of the 14-3-3 inhibitor in CA3 neurons leads to a faster decay of KAR-EPSCs at hippocampal mossy fiber-CA3 synapses .
In the 14-3-3 FKO mice, there is a reduction of both dendritic complexity and spine density in the cortical and hippocampal neurons where the 14-3-3 inhibitor is extensively expressed .
Abbreviations NMJ: Neuromuscular junction EJCs: Excitatory junctional currents EPSCs: Excitatory postsynaptic currents PTP: Posttetanic potentiation LTP: Long-term potentiation Difopein: Dimeric fourteen-three-three peptide inhibitor FKO: Functional knockout PSD: Postsynaptic density LIMK: LIM kinases SSH: Slingshot.
It was compiled by a group of researchers of the German department at Freiburg University in conjunction with the IDS in the periods 1968 - 1972 and 1974 - 1977 in order to further analyse the organisation of natural conversation (see FKO).
The three corpora held at the IDS (DSK, FKO, PFE) were searched with the help of COSMAS (Institut far deutsche Sprache, 1999); the fourth corpus (BRO) was searched using Microconcord (Scott & Johns, 1993).
It is most frequent in the BRO corpus with 33.7 occurrences per 1,000 words, followed by 19.8 in DSK, 13.4 in FKO, and 10.9 in PFE.
Although all the corpora comprise dialogues, the nature of these dialogues in FKO and DSK is rarely personal.