[2] Fundacao de Amparo ao Ensino, Pesquisa e Assistencia (FAEPA), Hospital das Clinicas,
FMRP, USP.
Recent work from the Shen group provides evidence that TDP-43 and
FMRP coregulate dendritic translation of ~160 common targets, including Rac1, GluA1, and Map1b [84].
Termino sus estudios de Magister em Ciencias Neurofisiologia en el Programa de Post-Grado en Fisiologia de la
FMRP con la Disertacion "Analise neuroetologica e quantitativa de mecanismos neurais envolvidos nas convulsoes audiogenicas no rato albino" (12/03/1982) y su Doctorado en Ciencias--Neurofisiologia en la misma Institucion y Programa de Post-Grado, con la Tesis laureada com honores maximos : "Analise do papel de estruturas da via acustica e sistema extrapiramidal na elaboracao de convulsoes audiogenicas no rato albino.
G4 Binding by the RGGGGR Peptide of the
FMRP Protein.
(c) The loss of
FMRP resulted in a decrease in the level of [beta]-catenin, then downregulated the expression of Ngn-1 and reduced neuronal differentiation.
hnRNP C has been known to stabilize APP mRNA or enhance its translation by competing with
FMRP, therefore positively regulates APP expression [171].
FMRP and GAPDH were detected by anti-FMRP (ab130165, Abcam) and antiGAPDH (ab9485, Abcam, USA) primary antibodies.
En los ultimos 15 anos se han hecho multiples avances en la descripcion de las caracteristicas genicas, funcion de la proteina codificada por el FMR1, la
FMRP; manejo farmacologico y la descripcion, en portadores de la premutacion, del sindrome de tremor y ataxia asociado al fragil X (FXTAS) y falla ovarica prematura asociada al SXF (FXPOI) (3-5).
The trinucleotide expansion of the CGG repetitive sequence in the fragile X mental retardation 1 (FMR1) gene of more than 200 repeats is termed full mutation (FM), and is usually associated with the "shut down" of the gene expression due to methylation of its promoter and loss of its protein product (
FMRP), which is essential for normal neurodevelopment (2-5).
This study was supported by the Conselho Nacional de Desenvolvimento Cientlfico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisado Estado de Sao Paulo (FAPESP), and Fundafao de Apoio ao Ensino, Pesquisa e Assistencia do Hospital das Cllnicas da
FMRP (FAEPA).