FNHTRFebrile Non-Hemolytic Transfusion Reaction (fever resulting from a blood transfusion)
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The highest incidence of TRs was found to be of FNHTR. this finding was in concordance with the study done by Khalid et al., [12] which reported the febrile non-hemolytic reaction (0.03%) was the most frequent ATR and it was followed by allergic reactions (0.02%).
[6] whole blood was implicated in anaphylaxis (31.7%), FNHTR (14%), transfusion-associated circulatory overload (3.84%), and TRALI (10%).
FNHTR being the most common, majority of the reactions occurred with whole blood followed by packed red cells, FFP and least with platelet concentrate.
The main nonfatal transfusion reactions described in the literature are febrile nonhemolytic transfusion reactions (FNHTRs), which are divided into nonsymptomatic (hyperthermia, due to an increase in temperature [greater than or equal to] 1[degrees]C, without other symptoms) and symptomatic.
FNHTRs is a reaction by the organism to the presence of cytokines, either through increased production of these mediators by leukocytes during blood storage, or through formation of immune complexes (antigens and antibodies) between antigens of the receptors and cytotoxic antibodies of the donor, thereby stimulating complementary action and production of pyrogenic cytokines (IL-6, TNF-[alpha], and IL-1/5) [21].
FNHTRs in humans maybe associated with the presence of hot and cold flushes and stiffness.
FNHTR does not normally require that transfusion be discontinued.