The median follow-up times were 45.0 months (2-132 months) and 44.6 months (2-132 months) in the FNMTC group and the SNMTC group, respectively.
We compared the clinicopathological features of the FNMTC group and the SNMTC group.
In terms of the prognosis, the incidence of persistence or recurrence of disease in patients with FNMTC was significantly higher than that of SNMTC patients (9.57% vs.
FNMTC had been regarded as an independent clinical entity that accounts for 3.3-8.9% of all thyroid cancer cases.,,, No consensus has been established on the typical clinical behavior and outcomes of FNMTC.
The number of multifocal tumors and bilateral lesions in FNMTC patients were significantly higher than in the controls, and these features have been confirmed in many other studies.
In our study, the FNMTC group exhibited a higher incidence of lateral cervical lymph node metastasis and extrathyroidal extension than to the control group.
discovered a higher recurrence rate (44%) in patients with FNMTC than in patients with SNMTC (17%), as well as a lower rate of DFS in familial forms than in sporadic forms. These results are consistent with the findings of Uchino et al .
Therefore, it is safe to presume that FNMTC-3-2 is more likely to be genuine FNMTC.
Familial non-medullary thyroid carcinoma (FNMTC): Analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations.
In general, 22.5-30.0% of thyroid carcinomas are multifocal; [sup], however, 33.6-48.0% of FNMTCs are multifocal.
The rate of invasiveness of FNMTCs was similar in FNMTC-2 group and FNMTC-3 group.
So far, no other published studies have investigated the clinicopathologic differences between FNMTC-3-2 and other FNMTCs. In our study, the ratio of FNMTC-3-2 aged <45 years was significantly higher than that in the other families (58.8% vs.