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Considering the distribution of disease, identified both by radiology and pathology studies, it seems plausible the fNSIP pattern is a response to a systemic disease process associated with blood flow, as opposed to inhalational exposure or anatomic forces.
The fNSIP pattern, regardless of etiology, has an improved prognosis when compared with UIP.
(27) Because of these features, and perhaps because UIP is the most well-known fibrosing interstitial pneumonia, it is not surprising that cases with fNSIP and ACF are often overcalled a UIP pattern.
The fNSIP pattern of fibrosis should involve most alveolar walls, without predilection for the airways or subpleural regions, but the extent of involvement is variable from one field to the next, with some alveolar walls approaching normal thickness.
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