Subsequent studies failed to demonstrate the presence of a putative fusion gene until 2014, when Walther et al, (19) using cytogenetics, fluorescence in situ hybridization, messenger RNA sequencing, and real-time polymerase chain reaction, demonstrated a balanced t(7;19)(q22;q13) translocation resulting in the fusion of the SERPINE1 and FOSB
genes in several cases.
The immunohistochemical panel is quite distinct: PHE expresses CD31, ERG, FLI1, and FOSB
, whereas epithelioid sarcoma is negative for these antibodies.
Other early responders include the stress transcription factors NF-KB, AP-1, FOSB
, and Elk-3.
In addition, genes located at the 19q13 are the BAX and BCL3 apoptosis related genes , genes involved in cell cycle progression that codify for cyclins, such as CCNE1, and genes codifying for transcription factors, such as FOSB
, among others .
Treatment of neuronal cells with etoposide, a Top II inhibitor which induces Top II-mediated DSBs , has been found to promote upregulation of a subset of nIEGs including Fos, FosB
, and Npas4 .
Moratalla, "ERK phosphorylation and FosB
expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice," Biological Psychiatry, vol.
For example, we previously identified activator protein 1 (AP1) family members such as FOSB
and JUND in plasma-treated blood cancer cell lines to be crucial .
Wei et al., "The effect of electroacupuncture on extinction responding of heroin-seeking behavior and FosB
expression in the nucleus accumbens core," Neuroscience Letters, vol.
miR-338-3p COL1A1; FOSB
; ADAMTS1; MMP9 miR-139-5p FOS Table 4: Top 10 significantly enriched pathways in KEGG pathway analysis.
Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB
and ERK activation in a 6-OHDA-lesioned Parkinson's disease mouse model.
However, during the second part of the experiment, mice that were given high-caffeinated drinks mixed with alcohol not only behaved in the same manner as mice who had been given cocaine but they had increased levels of the protein FosB
, which scientists say is responsible for long-term changes in the neurochemistry of the brain.