The present study is a prelimnary frequency study of FOXO
and its SNP rs2802288 in our population.
regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.
It would also be checked from translocating to the nucleus, which would keep the FOXO
transcription factors active at their respective normal levels, resulting in the expression and activities of antioxidant enzymes at their respective normal levels (Figure 4).
Galli, "PPAR[gamma] and oxidative stress: Con([beta]) catenating NRF2 and FOXO
," PPAR Research, vol.
Our enrichment analysis had classified these aberrant methylated genes as "cytokine-cytokine receptor interaction," "NF-kappa B signaling pathway," "FoxO
signaling pathway," and other signaling pathways, but only the aberrant genes of RA and pSS appeared in the proteasome signaling system (Figure 5(b)).
Once activated, PGC-1[alpha] interacts with the PPAR family of nuclear receptors  and the FOXO
family of transcription factors  to influence expression of a variety of bioenergetic and antioxidant proteins.
Olmos, "The complex biology of FOXO
," Current Drug Targets, vol.
Akhavan et al., "mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO
acetylation and upregulation of c-Myc," Cell Metabolism, vol.
(2015) Longevity genes revealed by integrative analysis of isoform-specific daf-16/ FoxO
mutants of Caenorhabditis elegans.
This is achieved by the E3-ubiquitin ligases regulating transcription of the Forkhead Box (FOXO
) proteins, including the FOXO3 isoform (Okamoto et al., 2011).
skeletal muscle FOXO
transgenic mice have less skeletal muscle mass, down regulated type 1 fiber genes and impaired glycemic control.
Tindall, "Dynamic FoxO
transcription factors," Journal of Cell Science, vol.