FPNLFriends of Princeton Nursery Lands (New Jersey)
References in periodicals archive ?
In our earlier study on cell culture [29], 6-OHDA increased the expression of hepcidin and decreased the expression of Fpnl, which made us design this current study to investigate the effect of hepcidin with knockdown experiments.
Hepcidin knockdown and subsequent upregulation of Fpnl protein significantly attenuated the protein oxidative damage induced by 6-OHDA, ultimately leading to a reduction in cell apoptosis, as evidenced by decreased caspase-3 activation and marginally decreasing DNA fragmentation.
Control siRNA: scrambled small interfering RNA; hepcidin siRNA: hepcidin small interfering RNA; Fpnl: ferroportin 1.