The study was carried out to compare the pharmacokinetics of optimized FPRTs of lercanidipine HCl and immediate release tablet (core).
Evaluation of FPRTs. Controlled-release floating pulsatile lercanidipine HCl tablets were prepared by compression coating of the optimized immediate release tablet (F 7) using polymer mixture containing PEO, sodium bicarbonate, and DCL.
FPRTs containing more concentrations of PEO also contained less amount of lactose.
Data obtained from all FPRT formulations were analyzed using Design-Expert software (version 8 trial, Stat-Ease, Inc., Minneapolis, MN) and used to generate the study design.