FRFPFamily Resource Facilitation Program (Canada)
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Foot process fusion rate (FRFP) = the total length of GBM/the sum length of fused foot process covered in the corresponding GBM.
Both FRFP and GBMT were alleviated by MET treatment compared to those of group DM (P < 0.05).
In the experiment, metformin decreased the level of TG, TC, and LDL-C, reduced the excretion of Ualb and Upcx, and relieved the FRFP. Therefore, we may infer that metformin develops its podocytes protection effect partly through ameliorating the level of lipid in DM rats.