FRNKFAK (Focal Adhesion Kinase) Related Non-Kinase
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The new protein inhibitor we designed, called FF, has proved to be far more potent than FRNK both in cultured cells as well as in the embryo suggesting that it would be a good candidate to explore further as a therapeutic agent," he said.
In the middle region of HC-Pro, the motif FRNK (623 to 626) was identified, which has been associated with aphid transmission and symptom expression (12).
A point mutation in the FRNK motif of the potyvirus helper component-protease gene alters symptoms expression in cucurbits and elicits protection against the severe homologous virus.