The collaboration is aimed at deciphering the governing principles of how pathological forms of TDP-43 spread from neuron to neuron, leading to a better understanding of the TDP-43 pathologies in order to support the Company's mission to develop novel therapeutic and diagnostic approaches against FTLD
and other neurodegenerative diseases.
Three major FTLD
clinical syndromes, described considering the predominant clinical manifestations, are the bvFTD, mainly featured by disturbances in social behavior and in executive functioning [64, 65]; the primary progressive aphasias (PPAs) (semantic variant (svPPA), nonfluent agrammatic variant (nfvPPA), and logopenic variant), a group of disorders mainly characterized by linguistic and behavioral alterations ); and the syndromes characterized by the cooccurrence of FTLD
with neurological disorders mainly affecting cortical and subcortical brain areas, including amyotrophic lateral sclerosis (ALS) , progressive supranuclear palsy (PSP), and the corticobasal syndrome (CBS) , which mainly affect motor functions, but also impact social behavior.
For the remainder of this article, the term "CARTS" is applied to this specific entity, and the term "HS" is used when the setting is less specific, for example, in the context of another degenerative disease process, such as FTLD
or ischemic/hypoxic injury without TDP-43 inclusions.
Another paradigm shift of so-called aggregates also undergoes in the field of front-temporal lobar degeneration (FTLD
In some ALS and FTLD
cases, however, the pathological SGs are colocalized with amyloidogenic deposits because the SG marker proteins TIA-1 and TDP-43 can form both SGs and insoluble fibrillary aggregates under pathological conditions and because SGs may function as seeds for irreversible aggregation (reviewed in ).
Frontotemporal lobe degeneration (FTLD
) refers to a neurodegenerative dementia syndrome, which could be clinically classified into behavioral and language variant.
Robinson et al., "Pattern of ubiquilin pathology in ALS and FTLD
indicates presence of C9ORF72 hexanucleotide expansion," Acta Neuropathologica, vol.
Grossman, "Distinct cerebral perfusion patterns in FTLD
and AD," Neurology, vol.
'Dollar Bank is pleased to have been an associate founder in the coalition of banks, trade associations and the American Bankers Association who partnered to establish fTLD
Of the 5,500 .BANK registration applications received to date by fTLD
, the operator of the .BANK registry, nearly half of them are through EnCirca.
More than 5,500 global banks -- including JPMorgan Chase and Wells Fargo -- have applied for the dot-bank domain to protect their institutions and customers from cyber breaches, according to Washington, D.C.-based fTLD
Registry Services, which manages the domain.
Registrars: Due to the enhanced security requirements in dot-bank, including mandatory verification of eligibility, the dot-bank domain can be registered from finance Top-Level Domain (fTLD