FVLM

(redirected from Factor V Leiden mutation)
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AcronymDefinition
FVLMFactor V Leiden Mutation
References in periodicals archive ?
Ulnar and radial DVT in a patient with factor V Leiden mutation is a rare condition.
Keywords: Factor V Leiden mutation, Recurrent pregnancy loss, PCR (Polymerase chain reaction).
Individuals with Factor V Leiden mutation therefore have decreased deactivation of both FVa and FVIIIa and increased risk of thrombosis.
[27], in an extended 10-year followup of a multicenter trial comparing secondary prophylaxis with vitamin K antagonists for 6 weeks versus 6 months that included 545 patients, found that neither carriage of factor V Leiden mutation or prothrombin G20210A polymorphism nor presence of cardiolipin antibodies was associated with an increased risk of developing PTS.
Hunter-Mellado, which describes three patients with Factor V Leiden mutation, two of which patients were found to have the prothrombin G20210A mutation (7).
(19.) Liebman HA, Kashani N, Sutherland D, McGehee W, Kam AL: The factor V Leiden mutation increases the risk of venous thrombosis in patients with inflammatory bowel disease.
Thrombotic screen testing revealed a heterozygous factor V Leiden mutation and a bleeding screen type I von Willebrand disease (vWD).
In this report, we present an interesting case of a combined heterozygote factor V Leiden mutation and anticardiolipin antibody positivity in a young patient with spontaneous deep vein thrombosis, which emphasizes importance of thrombophilia.
Tests for factor V Leiden include screening for activated protein C (APC) resistance, and if positive, testing for the Factor V Leiden mutation.
When underlying coagulation factors were assessed, 242 (27%) patients were found heterozygous for the factor V Leiden mutation, and 18 (2%) were homozygous.
"A woman between the ages of 28 and 45 with [genetic thrombophilia], such as the factor V Leiden mutation, and who also uses oral contraceptives has an increased risk of thrombosis, but she may ultimately manage to avoid having a thrombotic episode.