reductase (FAR) catalyzes the reduction of fatty acyl-CoA
to fatty alcohol, and FAR1 and FAR2 encode the reductase enzyme, which is needed for the first step of the wax biosynthesis.
reductase, encoded by IDG033 in wheat and Ms2 in Arabidopsis, is the key enzyme for the production of fatty alcohols in plastids .
The team found that medium-chain fatty alcohols could be produced in yeast by targeted expression of fatty acyl-CoA
reductase, or TaFAR, in the peroxisome of Saccharomyces cerevisiae.
ETC complex I and complex II, as well as other mitochondrial enzymes such as [alpha]-ketoglutarate dehydrogenase, pyruvate phosphate dehydrogenase, fatty acyl-CoA
dehydrogenase, and glycerol 3-phosphate dehydrogenase, can produce [O.sub.2.sup.*-]as byproduct, releasing it within the mitochondrial matrix.
Yield of ATP during oxidation of one molecule of saturated fatty acid with 16 carbons of fatty acyl-CoA
. Metabolic Enzyme catalyzing N.
Inouye, "Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-Coa
synthetase," Bioscience, Biotechnology and Biochemistry, vol.
 found that in hTNF-[alpha] transgenic mice, hepatic triglycerides were enhanced and accompanied by reduced hepatic mRNA levels or activities of CPT-II, mitochondrial HMG-CoA synthase, peroxisome proliferator activated receptor [alpha] (PPAR[alpha]), and fatty acyl-CoA
Free CoASH released from fatty acyl-CoA
intermediates by the methylketone cycle could be used by acyl-CoA oxidase and the thiolases, enabling fatty acid oxidation to continue .
We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished levels of L-carnitine, which would adversely affect carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for fatty acyl-CoA
uptake into mitochondria for beta]-oxidation.
The latter is an important mechanism in the heart where increased respiration results in a fall in mitochondrial acetyl-CoA, in turn leading to a fall in cytosolic malonyl-CoA, relieving inhibition of carnitine palmitoyl transferase 1 (CPT I) and thereby increasing transport of fatty acyl-CoA
into the mitochondria for oxidation .
Once inside the mitochondria, the fatty acyl-CoA
is degraded through four separate reactions.
This decrease in total activity in response to the olive oil- and corn oil-enriched diets but not to the coconut oil-enriched diet could be due to the inhibitory effect of long-chain unsaturated fatty acyl-CoA
on the synthesis and/or stability of acetyl-CoA mRNA, similar to that observed in the weaned rats .