The basic principles of drug selection, for the purpose of AR therapy, are based on the optimal ratio of efficacy and safety of use, on this basis, systemic AR treatment is usually limited to oral administration of antihistamines, mainly selective antiallergic action (fexofenadine
, desloratadine, levocetirizine), which are effective eliminate the main nasal symptoms of AR--sneezing, pruritus, rhinorrhea (22).
Mattila and Paakaari  reported in their study of newer non-sedating antihistamines fexofenadine
, loratadine, acrivastine, astemizole, cetirizine, astemizole and terfenadine however not entirely free from central effects and there at astemizole quantitative differences between them psychomotor and sleep studies in the healthy subjects in laboratory may predict that antihistamine does not cause drowsiness; but the safety margin is narrow enough to cause a central sedating effect during actual treatment.
is an antihistamine used to relieve allergy symptoms such as hay fever and sinus congestion.
The company's Fexofenadine
Hydrochloride and Pseudoephedrine Hydrochloride Extended Release Tablets 60 mg/120 mg are offered in 20 count blister packs.
The ion transitions monitored were mass-to-charge ratios of 502.2-466.5 (fexofenadine
) and 285.2-193.1 (internal standard).
In our study fexofenadine
was found to react with permanganate in alkaline medium; the reaction yielded a bluish green manganate with a [[lambda].sub.max] at 610 nm.
Because there are no reports for fexofenadine
, other antihistamines might be a better choice.
55 Teva USA Fexofenadine
HCI 00093725301 $197,514,723
In the study, volunteers took fexofenadine
, an antihistamine used to fight allergies, with either a single glass of grapefruit juice, water containing only naringin (the active ingredient of grapefruit juice), or water.
Volunteers tested fexofenadine
, an antihistamine used for allergies.
KYOTO, JAPAN -- Fexofenadine
is the sole truly nonsedating antihistamine--and the only one that does not cause objectively measurable cognitive and psychomotor impairment at doses commonly used in clinical practice, said Dr.
Allegra ODT (fexofenadine
HCl orally disintegrating tablet, 30 rag, Sanofi Aventis)