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The aim of this study was to investigate the expression pattern of VEGF and flk-1 in three components (luminal epithelium, glandular epithelium and stroma) of human endometrium during different phases of menstrual cycle using tissue microarray (TMA) analysis.
Binding of VEGF or Flk-1 was detected by a biotinylated rabbit antimouse secondary antibody, followed by HRP conjugated avidin-biotin perioxidase.
Immunohistochemical labelling of VEGF, Flt-1, Flk-1, caspase-3, caspase-9, caspase-8 and Fas/FasL and TUNEL staining for detection of apoptotic cells were performed.
Circulating mature endothelial cells (CECs) may appear in the circulation by detaching from activated or damaged vessels and express CD34 and Flk-1, but, unlike the EPCs, they are negative for the haematopoietic marker CD45.
The number of cells positive for both Flk-1 and Sca-1 (Flk-1+/Sca-1+) and those positive for Sca-1 alone (Sca-1+) were measured by flow cytometry using an LSRII flow cytometer (BD BioSciences) and analyzed with FlowJo v8 software (Treestar Inc.
ImClone Systems Incorporated (Nasdaq:IMCL) announced preclinical findings from a study which immunized mice with the FLK-1 protein to elicit an immune response against angiogenesis, the formation of new blood vessels associated with tumor growth.
The Company's DC101 monoclonal antibody targets a receptor of the Vascular Endothelial Growth Factor (VEGF) referred to as FLK-1 in mice and KDR in humans.
The Company's monoclonal antibody targets a receptor of the Vascular Endothelial Growth Factor (VEGF) referred to as FLK-1 in mice and KDR in humans.
According to the research protocol, ImClone scientists will seek to stimulate the immune system to target Flk-1, a key receptor in blood vessel formation, which binds to vascular endothelial growth factor (VEGF).
In preclinical studies, the Company has demonstrated that inhibition of the VEGF receptor flk-1 (the mouse equivalent of KDR) in mice results in a potent inhibition of angiogenesis, tumor growth and metastasis.
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