In a paper titled "The Extracellular Matrix and Focal Adhesion Kinase
Signaling Regulate Cancer Stem Cell Function in Pancreatic Ductal Adenocarcinoma," Verastem researchers, along with scientific collaborators led by William Matsui at Johns Hopkins University School of Medicine, describe findings demonstrating that FAK inhibition extended the anti-tumor response to gemcitabine and nab-paclitaxel (Gem-Pac) in preclinical models of PDAC.
sup],, They can sense mechanical stimuli, mediate mechanical force transfer across the cell surface and through their interconnections with focal adhesion kinase
(FAK), and transduce into biochemical signals to regulate cell behavior.
In contrast, Src is barely detectable in resting macrophages and is greatly up-regulated by LPS, leading to focal adhesion kinase
(FAK) activation and cell motility (Chen et al.
Mouse monoclonal FITC-conjugated antihuman factor VIII, mouse monoclonal antibody antihuman focal adhesion kinase
(anti-p125FAK), and rabbit polyclonal antibodies anti-human ERK1 and anti-ERK2 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
Reactive oxygen species activate focal adhesion kinase
, paxillin and p130cas tyrosine phosphorylation in endothelial cells.
Walden PD, Globina Y, Nieder A (2004) Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase
VS-6063 (defactinib) is an orally available compound designed to target cancer stem cells through the potent inhibition of focal adhesion kinase
A recent study by Jan et al has shown a correlation between over-expression of focal adhesion kinase
and extrahepatic metastatic sites in patients with HCC (5).
Vairaktaris et al also found that diabetes may increase risk for oral cancer through the insulin receptor substrate-1 and focal adhesion kinase
Purpose: The focal adhesion kinase
(FAK) is an intracellular tyrosine kinase associated with the regulation of cell growth, migration and survival, and has been linked to oral squamous cell carcinoma (OSCC).
This target has now been confirmed as the Focal Adhesion Kinase
(FAK), a protein involved in many cancers.
Among the topics are the potential of bone marrow stomal stem cells to repair bone defects and fractures, diminishing gene expression in human mesenchymal stem cells by the mutation of focal adhesion kinase
signaling, and differentiating multiple neuronal subtypes from mouse embryonic stem cells.