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Detection of fragile X mental retardation
protein (FMRP): Peripheral blood smear on glass slides were collected and stored at -20[degrees]C (<2 wk).
For testing the requirement of various candidate proteins for function of the fragile X mental retardation protein, the researchers genetically modified the flies to prevent them from making each candidate protein.
It was found that loss of any one of the five proteins caused the fruit fly's eye to be significantly less deformed, revealing that each is required for function of the fragile X mental retardation protein.
To top it all, even the fragile X mental retardation protein didn't have any effect on bantam.
A growing body of research has led to the "mGluR theory of fragile X mental retardation
," which suggests that unchecked signaling by group 1 metabotropic glutamate receptors (mGluRs) contributes to the many central nervous system symptoms of fragile X (Trends Neurosci.
The research team claim to have developed specific and quantitative means of measuring levels of the fragile X mental retardation
1 (FMR1) protein (FMRP), which is mutated in fragile X syndrome.
The master gene behind the syndrome encodes a protein--called FMRP, for fragile X mental retardation
protein--that binds to strands of messenger RNA (mRNA).