The protein, called the A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor
(GPCR) family, which are the targets of roughly 40 percent of all approved pharmaceuticals.
Most of these channels were annotated as being from the degenerin/epithelial sodium channel family or the G-protein-coupled receptor
family; proteins from these families can have chemosensory functions.
Their topics include post-translational modifications of tubulin and cilia, the central apparatus of cilia and eukaryotic flagella, transition zone migration: a mechanism for cytoplasmic ciliogenesis and postaxonemal centriole elongation, primary cilia and mammalian hedgehog signaling, G-protein-coupled receptor
signaling in cilia, ciliary mechanisms of cyst formation in polycystic kidney disease, sperm sensory signaling, cilia and ciliopathies in congenital heart disease, photoreceptor cilia and retinal ciliopathies, and the evolution of cilia.
Naor, "Signaling by G-protein-coupled receptor
(GPCR): studies on the GnRH receptor," Frontiers in Neuroendocrinology, vol.
It builds on my recent results which showed that in one photoreceptor neuron subtype of fruit fly Drosophila melanogaster, a green-sensitive Rhodopsin6 (Rh6, a G-protein-coupled receptor
that detects photons) not only functions in the phototransduction, but also signals to maintain repression of the sister receptor gene, the blue-sensing Rh5.
Leucine-rich repeat-containing G-protein-coupled receptor
5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer.
Molecular Devices has introduced its ClonePix 2 system, proven effective for rapidly assessing endogenous G-protein-coupled receptor
(GPCR) target protein expression levels in mammalian cell lines and selecting high expressing clones.
Epidermal growth factor receptor(EGFR) transactivation by estrogen via the G-protein-coupled receptor
, GPR30: a novel signaling pathway with potential significance for breast cancer.
Using green fluorescent protein to understand the mechanisms of G-protein-coupled receptor
Molecular cloning and characterization of a novel human G-protein-coupled receptor
, EDG7, for lysophosphatidic acid.
Stains for the stem cell marker, known as Lgr5 (leucine-rich repeat-containing G-protein-coupled receptor
5), showed two patterns of expression in taste tissue.
Activation of free fatty acid receptor 1 (FFAR1), which is also known as G-protein-coupled receptor
40, has been shown in preclinical studies to stimulate glucose-dependent beta-cell insulin secretion.