G6PIGlucose-6-Phosphate Isomerase
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ICOSL and its importance in antibody-mediated disease have also been verified in several preclinical models of human disease including RA, SLE, and uveitis [32, 36, 42-46] as well as in other models of arthritis (proteoglycan-induced arthritis (PGIA) and glucose-6-phosphate isomerase- (G6PI) induced arthritis), exemplifying the utility of anti-ICOSL-binding domains in the treatment of this immune disorder [44, 47, 48].