G93AGlycine-93 to Alanine
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Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS.
The expression of caspase-11 is up-regulated in the spinal cord of superoxide dismutase 1 (SOD 1) G93A transgenic mice, a mouse model of ALS, before the onset of motor dysfunction and remains at the high levels throughout the course of disease (65).
Pioglitazone also reduces gliosis and iNOS, NFkappa-B, and 3-nitrotyrosine immunoreactivity in the spinal cords of G93A SOD1 transgenic mouse model of ALS (71).
Oral administration of either celecoxib or rofecoxib, specific COX-2 inhibitors, significantly improve motor performance, attenuate weight loss and extended survival in the G93A transgenic mouse model of ALS.
used for genotyping the hMLH1 G93A polymorphism are shown in Table 1.
The results obtained for 196 genomic DNA samples from patients with hematologic malignancies analyzed for the G93A locus are shown in Fig.
2+] capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice," Journal of Neurochemistry, vol.