GABA-B

AcronymDefinition
GABA-BGamma-Amino-Butyric Acid Type B
References in periodicals archive ?
Key words: GABA-B receptor antagonist, hypoxia ischemia, serum triglycerides, transaminases, lipoproteins.
GABA brings about its function through GABA-A which is ionotropic and GABA-B metabotropic receptors.
GABA-B receptor antagonist CGP 55845 selectively involve in behavioral learning, increasing swimming time in rat modified forced swim test.
The company said that with this efficacy and safety profile of its GABA-B receptor PAM oral small molecules, the programme is on track for IND filing before the end of 2012.
Lithium, carbamazepine, and valproate have been found to increase the effect of GABA-B receptors while decreasing GABA turnover.
GABA-B receptors play an important role in modulating the release of glutamate and optimizing the ratio of excitatory to inhibitory neurotransmission.
Studies examining induced seizure activity in mice suggest that the opposing actions of mGluRs and GABA-B receptors provide a therapeutic path for fragile X syndrome.
GABA-B receptors play an important role in modulating the release of glutamate and maintaining the optimal excitatory-inhibitory balance.