GABA-BGamma-Amino-Butyric Acid Type B
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Key words: GABA-B receptor antagonist, hypoxia ischemia, serum triglycerides, transaminases, lipoproteins.
GABA brings about its function through GABA-A which is ionotropic and GABA-B metabotropic receptors.
GABA-B receptor antagonist CGP 55845 selectively involve in behavioral learning, increasing swimming time in rat modified forced swim test.
The company said that with this efficacy and safety profile of its GABA-B receptor PAM oral small molecules, the programme is on track for IND filing before the end of 2012.
Lithium, carbamazepine, and valproate have been found to increase the effect of GABA-B receptors while decreasing GABA turnover.
Ching stayed on in the lab to learn neurobiology -- an experience that led to his discovery that optic nerves contain a chemical receptor known as GABA-B. He also found that a related chemical boosts nerve conduction in vitro and shows potential for treating spinal injury and multiple scierosis.