Next to AP-325 Algiax has discovered novel GABAA
receptor modulator compounds called Thioacrylamide derivatives.
Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA
receptors and behavioral stress responses.
Effects of status epilepticus on hippocampal GABAA
receptors are age-dependent.
The study results stimulated the development of drugs that target the GABAA
receptor a2 subunit as new, more effective treatments for epilepsy.
Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA
and GABArho receptors.
It targets GABAa
receptors, according to presenter Christine Clemson, PhD, senior medical director at Sage Therapeutics, the company developing brexanolone.
The mechanism of action of lorazepam, diazepam, and phenobarbital is to enhance activation of gamma-aminobutyric acid agonist (GABAA
receptor [gamma]2 subunit is palmitoylated on unique cysteine residues localized within a major intracellular domain .
OVIOI, a delta (d)-selective GABAA
receptor agonist, is believed to be the first investigational drug to target the disruption of tonic inhibition, a key mechanism that allows the brain to decipher excitatory and inhibitory neurological signals correctly without being overloaded.
Much like alcohol or benzodiazepines, ALLO is a potent positive allosteric modulator of GABAa
receptors and has sedative, anesthetic, and anxiolytic properties.
Dentre os anticonvulsivantes relacionados ao aumento do risco de tonturas, destacam-se aqueles que inibem a funcao dos canais de sodio voltagem dependente como a lamotrigina, oxcarbazepina, a carbamazepina; aqueles que potencializam a acao do GABAa
como os benzodiapinicos (clonazepam), o fenobarbital e tem como provavel mecanismo da reacao adversa a hipotensao ortostatica e disfuncao cerebelar [2,16].
Orser, "Pharmacological enhancement of A-subunit-containing GABAA
receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice," Pain, vol.