GAD65Glutamic Acid Decarboxylase 65-kDa
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In the human brain, GAD65 performs an essential role: it makes 'neurotransmitters' - chemicals that pass messages between brain cells.
Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test.
Diamyd Medical's research program was preceded by studies from the early 1980s where Professors Johnny Ludvigsson, Ake Lernmark, and Steinun Baekkskov discovered the autoantigen that later proved to be GAD65, the active ingredient in the Diamyd(TM) therapeutic.
Development projects within the area of diabetes originates from the protein GAD65 for the treatment and prevention of autoimmune diabetes.
Autoantibodies against insulin, GAD65, and IA-2 were measured in 13 377 children who were followed for 15 years.
Stiff-person syndrome: Quantification, specificity, and intrathecal synthenthesis of GAD65 antibodies.
Diamyd also retains the rights to the therapeutic use of the GAD65 gene and derivatives, fragments and variants of the GAD65 protein.
The Company's development project consists of the protein GAD65 for the treatment and prevention of autoimmune diabetes.
lalpha,25-dihydroxyvitamin D3 induces an autoantigen-specific 1-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 fp524-5431.
Unfortunately, the international WHO standard serum for antibodies to GAD65 and IA-2 (27, 28), which could have provided a ready source, is negative for ZnT8A antibodies (A.
Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice.