The patient was diagnosed with GAD65
antibody positive autoimmune encephalitis.
Subsequent CSF analysis revealed increased GAD65
antibodies 1.83nmol/l, normal <= 0.02.
Pietropaolo et al., "Combined analysis of GAD65
and ICA512 (IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus," Journal of Autoimmunity, vol.
vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes," Diabetologia, vol.
The expressions of both isoforms of GAD (GAD65
and GAD67) were found not to be different in hippocampal homogenate of db/db mice.
High concentrations of glucose induce the production of GAD65
in b-cells which is associated with an increase in GAD65
Esto se ha asociado a una reduccion en la expresion de GAD65
y GAD67 (35).
The path which the destruction of the cell traverses is antibodies destruction, insulin reduction and GAD65
affected by auto antibodies that are affected.
Immunohistochemical localization of GABA, GAD65
, and the receptor subunits GABAAalpha1 and GABAB1 in the zebrafish cerebellum.
These autoantibodies include anti-Hu, NMDAR, voltage-gated calcium channel (VGCC), glutamic acid decarboxylase 65 (GAD65
), Sex determining region Y-box 1 (SOX1) and amphiphysin antibodies, as previously reported.
(veya amfifizin) otoantikorlari icin pozitif seroloji 6.
Glutamic acid decarboxylase (GAD65
) and thyroid antibodies in Omani patients with type 2 diabetes.