GAD65Glutamic Acid Decarboxylase 65-kDa
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The patient was diagnosed with GAD65 antibody positive autoimmune encephalitis.
Subsequent CSF analysis revealed increased GAD65 antibodies 1.83nmol/l, normal <= 0.02.
Pietropaolo et al., "Combined analysis of GAD65 and ICA512 (IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus," Journal of Autoimmunity, vol.
Lernmark, "GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes," Diabetologia, vol.
The expressions of both isoforms of GAD (GAD65 and GAD67) were found not to be different in hippocampal homogenate of db/db mice.
High concentrations of glucose induce the production of GAD65 in b-cells which is associated with an increase in GAD65 gene expression.
The path which the destruction of the cell traverses is antibodies destruction, insulin reduction and GAD65 affected by auto antibodies that are affected.
Immunohistochemical localization of GABA, GAD65, and the receptor subunits GABAAalpha1 and GABAB1 in the zebrafish cerebellum.
These autoantibodies include anti-Hu, NMDAR, voltage-gated calcium channel (VGCC), glutamic acid decarboxylase 65 (GAD65), Sex determining region Y-box 1 (SOX1) and amphiphysin antibodies, as previously reported.
Glutamic acid decarboxylase (GAD65) and thyroid antibodies in Omani patients with type 2 diabetes.