GAD67Glutamic Acid Decarboxylase 67 Kd
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(g, h) Dual immunofluorescence of (g) TH (red) and GAD67 (green) and (h) TH (red) and VGLUT2 (green) in neuronal cultures at day 70.
* GABA uptake and metabolism is controlled by the enzyme glutamic acid decarboxylase (GAD); depression has been found to be associated with a polymorphism in the GAD67 gene encoding an iso-form of GAD.
Herrero et al., "Alterations of GABAergic neurons in the basal ganglia of patients with progressive supranuclear palsy: an in situ hybridization study of GAD67 messenger RNA," Neurology, vol.
The different mechanisms suggested for the role of human cytomegalovirus in diabetogenesis maybe related to (1) molecular mimicry induced by T-cell cross-reactivity between human cytomegalovirus and GAD65 (glutamic acid decarboxylase exists as two isoforms GAD65 and GAD67, a major enzyme required for the production of the gamma amino butyric acid which regulates the glucagon secretion) in pancreatic islet [beta]-cells [102, 103]; (2) the persistence of HCMV specific CD4+ T-cells or a bystander activity [104]; and (3) persistent infection in [beta]-cells [127].
Webster, "Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders," Journal of Psychiatry & Neuroscience, vol.
The enzyme has two isoforms, namely a membrane-associated 65 kDa form, GAD65, and the soluble 67 kDa form, GAD67. [21] These isoforms differ in structure and function.
Autoantibody Autoantigen ICA The ICA autoantigens are not well defined but include a sialoglycoconjugate and glutamic acid decarboxylase (34) 1AA Insulin (proinsulin antibodies have also been demonstrated) GADA Glutamic acid decarboxylase (GAD65 > GAD67) 1A-2A A protein tyrosine phosphatase (PTP) ZnT8A Zinc transporter-8 that transports zinc into insulin secretory granules ICA = lslet cell cytoplasmic autoantibodies; IAA = Insulin autoantibodies; GADA = Glutamic acid decarboxylase autoantibodies; 1A-2A = Insulinoma associated-2 autoantibodies; ZnT8A = Zinc trasnporter-8 autoantibodies Table 1.
Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications.
GAD65, GAD67, IA-2, IA-2[beta], karboksipeptidaz-H, osteopontin gibi bircok yapiya karsi gelisen antikorlarin ayni zamanda ICA olarak da belirdigi gosterilmistir.
Although there are 2 major isoforms of GAD, GAD autoantibodies are more often found that are directed against GAD65 (65 000-Da molecular weight) than GAD67 (67 000-Da molecular weight).