GAERSGenetic Absence Epilepsy Rat from Strasbourg (laboratory rat strain)
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
In the GAERS rats, CX-8998 showed near complete suppression of seizure activity (99% reduction in both number and cumulative duration of spike wave discharges) at 10 mg/kg, a well-tolerated dose that results in human-achievable drug concentrations.
The absence seizures in FMUSP rats occur predominantly during attentive wakefulness, as observed in humans (HALASZ, 1972; 1981; MONTPLAISIR et al., 1985) and in GAERS rats (PINAULT et al., 2006), which probably accounts, at least partially, for a 19.8% reduction of the mean incidence in wakefulness.
(2000) found that GAERS rats exhibit stable amounts of wake state and slow wave sleep, distributed through clear circadian rhythms, analogous to those of Wistar non-epileptic animals, with a quantitative deficit in PS.
I played in five games last season and I have to say thank you to the gaer for the opportunity to show what I can.
Another extensively examined model of spontaneous epilepsy is the GAERS rat (Genetic Absence Epilepsy Rats from Strasbourg) (MARESCAUX et al., 1992) presenting seizures with high voltage (250-800 pV) 7-10 Hz discharges lasting 0.5 to 7.5 seconds.
However, abnormal hippocampus activity was not found during seizures in WAG/Rij (COENEN et al., 1992) or in GAERS rats (DANOBER et al., 1998) but were consistently present in the FMUSP-rats.
Benzodiazepines have reduced the severity of absence and myoclonic seizures in humans (MELDRUM; ROGAWSKI, 2007) and suppressed pentylenetetrazol-induced seizures (MARES; SLAMBEROVA, 2006) as well as those in GAERS and other rodent models (COENEN; VAN LUIJTELLAR, 1989; DANOBER et al., 1998; COENEN; VAN LUIJTELAAR, 2003) by acting on [GABA.sub.A] receptors.