GCLC

AcronymDefinition
GCLCGlutamate-Cysteine Ligase, Catalytic Subunit
GCLCGreater Cincinnati Library Consortium
GCLCGeorgia Collegiate Leadership Conference (various schools)
GCLCGlobal Competition Law Centre (est. 2004; College of Europe; Belgium and Poland)
GCLCGotham City Land Cruisers (New York)
GCLCGreater Columbia Literacy Council (Columbia, SC)
GCLCGolden Casket Lottery Corporation (Queensland, Australia)
References in periodicals archive ?
He also sought proposals of the business and industrial community in respect to composition and TORs of GCLC.
Exercise induced upregulation of glutamate-cysteine ligase, catalytic subunit (GCLC) and glutamate-cysteine ligase, modifier subunit (GCLM) gene expression in Thoroughbred horses.
GCLC has developed the technology and expertise for the mass production of human NK cells by successfully conducting a first-in-human clinical trial using healthy donor-derived allogeneic NK cells and by developing CAR-NKs to enhance anti-tumor specificity and efficacy.
Aldosterone significantly decreased the expression of GCLC and Nrf-1 compared with the untreated control (Figures 7(a) and 7(b)), while it increased Nox4 expression (Figure 7(c)).
In BMM, IFN-[alpha] reprogramming was associated with increased expression of genes associated with nitric oxide (NO) production (ASS1, NOS1, and NAGS) and decreased antioxidants (SOD2, GCLC, TXNRD1, and TXNRD3).
This finding is in agreement with the results obtained in solitary ascidians, which saw an increase in the transcription of genes for GCLC, GCLM, GS, metallothioneins, phytochelatin synthase, and SODb in Ciona intestinalis after treatment with 10 [micro]mol [l.sub.-1] Cd[Cl.sub.2] (Franchi et al., 2011, 2012, 2014; Ferro et al., 2013).
For the amplification of regions capturing the GCLM (-588C/T) and GCLC (-129T/C) polymorphic sites, we used primers as described by Nakamura et al.
The nuclear translocation of Nrf2 was associated with increased expression of Nrf2 target genes heme oxygenase 1 (HO-1, p < 0.001), glutamate-cysteine ligase catalytic subunit (GCLC, p = 0.04) and glutamate-cysteine ligase regulatory subunit (GCLM, p <0.001) (Figure 4(c)).
Furthermore, accumulating data are showing that Nrf2 is the crucial regulator of apoptosis by activating antioxidant cascades, such as HO-1, GCLC, and NQO1 [15, 16], which contribute to the suppression of apoptosis.
To further confirm whether Nrf2-downstream genes are involved, mRNA levels of HO-1, GCLC, and MRP2 were analyzed (Figure 9).
Tan was able to activate Nrf2 and increase the expression levels of Nrf2 target genes, including glutamate-cysteine ligase catalytic subunit (GCLC), NAD(P)H:quinine oxidoreductase 1 (NQO1) and hemeoxygenase-1 (HO-1), in a dose-dependent manner in HepG2 cells.