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Phenytoin was administered in a single daily dose (75 mg Kg-1 bd.wt.) to pregnanty rats in GD9 to GD11 days of gestation, during organogenesis.
The aim of the present study was to determine, by kariometric parameters, the influence of phenytoin, as teratogen, on the epithelial layer of choroid plexus in rats fetuses, with lowest total dose used (225 mg Kg-l), to the best of our knowledge (Table I), using a single daily dose (75 mg Kg-1 bd.wt.) on days GD9 to GD11.
Based on dam weight at GD7, pregnant rats (n = 6/dose) were implanted with pumps on GD9 to deliver vehicle, BPA25, or BPA250, and blood was collected by cardiac puncture 72 hr later.
We recorded weights of pregnant females on GD0, GD6, GD9, GD12, GD15, and GD18.
One group of pregnant rats received 0, 1, 2, or 5 mg/kg daily from GD9 to GD12, and determinations were conducted on GD17 and GD21.
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- Gdansk Institute for Market Economics
- Gdansk Shipyard
- Gdansk University of Technology