GFAP+Glial Fibrillary Acidic Protein Positive
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This is best demonstrated on a morphological level by the dense GFAP+ envelope surrounding the blood vessels.
Quantification of PCNA+ and Iba1+ cells was obtained from the PCNA/Iba1/A[beta] stained slides, while quantification of GFAP+ cells was obtained from the PCNA/GFAP/A[beta] triple stained sections.
We first studied GFAP+ and PCNA+ cells across cohorts to evaluate any association between the two protein markers.
GFAP+ astrocytes showed a characteristic, spider-like cellular morphology.
The population of A[beta] plaques with invasive hypertrophic GFAP+ astrocytes was increased in the AD population (one-way ANOVA P < 0.001).
Since GFAP+ astrocytes were not colabeled with PCNA, we next used combined Iba1-PCNA double immunocytochemistry to test whether proliferation did occur in microglial cells.
PCNA+ profiles were never observed in mature neurons or GFAP+ astrocytes, indicating that these cell types do not proliferate or reenter the cell cycle during dementia or AD.
Each patent claims a cell culture of undifferentiated GFAP+ Nestin+ cells wherein one or more cells have the capacity to differentiate into neurons and glia as do many neural stem and progenitor cells described by researchers.
GFAP+ astrocytes forming the glial scar around the infarct adopted a bipolar form in OPN-treated animals (Figures 5(a) and 5(b)).