Type 1 neuregulins (NRG-1) are a protein family of structurally related growth factors comprised of glial growth factor (GGF) (1,2), neu differentiation factor (NDF) (3), acetylcholine receptor inducing activity (ARIA) (4), heregulin (HER) (5) and sensory and motor neuron-derived factor (SMDF) (6).
Due to the difficulty of purifying enough quantities of these proteins and the lack of specificity from commercially available antibodies, the aim of this work was to produce antibodies capable of identifying different glial growth factor isoforms (GGF).