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More careful study showed this protein lacked [Kappa] and [Lambda] light chains, observations consistent with GHCD (Figure 2, B).
The clinical course of GHCD is highly variable, with survival times ranging from a few months to 20 years.
Wester et al summarized the histopathologic findings of 8 new cases, as well as the 66 previously reported cases of GHCD. Of the 74 total cases, 53 presented with disseminated lymphoproliferative disease, while 21 presented with localized lymphoproliferative disease.
While the association of Hodgkin disease with monoclonal gammopathy is rare,[2-6] the association with GHCD is extremely rare.
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