In the functional pathway of neuroactive ligand-receptor interaction, 5 genes NMUR2, GHSR
, NMBR, GNRHR, and F2RL3 were involved.
As an endogenous ligand of GHSR
, ghrelin was first isolated from the stomach of rats [4-6], and GHSR
mRNA was expressed in the whole gastrointestinal tract and hypothalamus.
The report provides comprehensive information on the Growth Hormone Secretagogue Receptor Type 1 (GHS-R or GH-Releasing Peptide Receptor or GHRP or Ghrelin Receptor or GHSR
), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
We investigated if ghrelin exerts its inhibitory effects on HO-8910 cells through GHSR
activation and the downstream activity of MAPKs.
Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor (GHSR
) and is the first hormone linking gastrointestinal-pituitary axis.
Thus, the abovementioned genes, e.g., IGFBP 1-3, ODC, CCKAR, GHSR
, and IGF1R, are not objects of our interest, since they are not located on chromosome 1.
In GC cells (a somatotrope tumor cell line) treated by GHRP-6 it has been observed that GHS increases GH release activating a G-protein coupled to the GHS receptor (GHSR
), which activates the [IP.sub.3]-PKC signaling pathway .
is expressed in lymphocytes, the action of ghrelin directly to preserve lymphocytes cannot be ruled out.
The effects of ghrelin are mediated via specific receptors, named the GH secretagogue receptors (GHSR
Ghrelin is secreted by X/A-like cells found in the gastric mucosa, and it binds to the growth hormone secretagogue receptor (GHSR
) present at the end of the vagus nerve to stimulate feeding behavior by suppressing the satiety stimulus transmitted by CCK [6, 7].
Ghrelin was first discovered as an endogenous ligand for growth hormone secreting receptor (GHSR
) (Kojima et al., 1999).
This is required for ghrelin to bind to the growth hormone secretagogue receptor (GHSR
) for its entry into the hypothalamus and pituitary gland, and to affect food-intake (26).