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Due to the tight association between an unbalanced lipid homeostasis and foam cell formation seen in diverse inflammatory conditions, we investigated the participation of distinct lipid homeostasis-related factors, such as the transcription factors PPAR-[gamma] and PPAR-[beta]/[delta], the ER enzymes DGAT and ACAT, and CD36 scavenger receptor in LD formation induced by the snake venom GIIA [sPLA.sub.2], MT-III, in macrophages.
Lipid droplet formation induced by a snake venom GIIA [sPLA.sub.2] in macrophages depends on lipid metabolism factors mainly PPAR-[gamma] and PPAR-ft/8, providing new insights into mechanisms of macrophage foam cell formation.