According to Vassiliev (1995), Voloshinov--after the reformulation of the GIRK
in 1932, when the literature sector was eliminated, and the linguistics sector became the basis for the Linguistic Institute of Leningrad--he gave classes at the Pedagogical Institute A.
Molecular mechanisms of analgesia induced by opioids and ethanol: Is the GIRK channel one of the keys?
Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain.
In general, these G-proteins activate GIRK
potassium channels, inhibit voltage-gated calcium channels, inhibit adenylyl cyclase, or activate phosphorylation of certain intracellular protein kinase enzymes (Fredholm et al.
While alcohols have been previously shown to open up GIRK channels, no study ever determined whether this was a direct effect or whether this was the by-product of other molecular changes in the cell.
The researchers say that the identification of the location of a physical alcohol-binding site important for GIRK channel activation could point to new strategies for treating related brain diseases.
Alternatively) If we could find a novel drug that fits the alcohol-binding site and then activate GIRK channels, this would dampen overall neuronal excitability in the brain and perhaps provide a new tool for treating epilepsy," says Slesinger.
In this case, the cells were manipulated to express GIRK
B] receptor mediated inhibitory transmission in brain neurons by facilitating GIRK currents (Federici et al.
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.