GIRK

AcronymDefinition
GIRKG-Protein-Gated Inwardly Rectifying K+ (neurotransmitter)
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According to Vassiliev (1995), Voloshinov--after the reformulation of the GIRK in 1932, when the literature sector was eliminated, and the linguistics sector became the basis for the Linguistic Institute of Leningrad--he gave classes at the Pedagogical Institute A.
VALENTIN NIKOLAIEVITCH VOLOSHINOV: DOCUMENTED DETAILS OF HIS LIFE AND WORKS
Molecular mechanisms of analgesia induced by opioids and ethanol: Is the GIRK channel one of the keys?
Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain.
Advances in electrophysiological research
In general, these G-proteins activate GIRK potassium channels, inhibit voltage-gated calcium channels, inhibit adenylyl cyclase, or activate phosphorylation of certain intracellular protein kinase enzymes (Fredholm et al.
Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol
While alcohols have been previously shown to open up GIRK channels, no study ever determined whether this was a direct effect or whether this was the by-product of other molecular changes in the cell.
The researchers say that the identification of the location of a physical alcohol-binding site important for GIRK channel activation could point to new strategies for treating related brain diseases.
Alternatively) If we could find a novel drug that fits the alcohol-binding site and then activate GIRK channels, this would dampen overall neuronal excitability in the brain and perhaps provide a new tool for treating epilepsy," says Slesinger.
Scientists identify alcohol-binding site in the brain
In this case, the cells were manipulated to express GIRK channels.
Shared mechanisms of alcohol and other drugs
B] receptor mediated inhibitory transmission in brain neurons by facilitating GIRK currents (Federici et al.
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.
Discovering genes involved in alcohol dependence and other alcohol responses role of animal models: role of animal models
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