Also found in: Idioms.
GIRKG-Protein-Gated Inwardly Rectifying K+ (neurotransmitter)
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
Molecular mechanisms of analgesia induced by opioids and ethanol: Is the GIRK channel one of the keys?
In general, these G-proteins activate GIRK potassium channels, inhibit voltage-gated calcium channels, inhibit adenylyl cyclase, or activate phosphorylation of certain intracellular protein kinase enzymes (Fredholm et al.
LeDai, author of Go Girk Finding Adventure Wherever Your Travels Lead, believes any woman--and man, too--can find an enriching experience, whether she travels to India, Japan, Antarctica, out of state on a business trip or to a nearby state park for a weekend retreat.
Slow voltage ramps (-130 to 20 mV) revealed that the outward current induced by NE reversed at the predicted equilibrium potential for potassium ([K.sup.+]) ions and showed prominent inward rectification, suggesting that NE activates G protein-coupled inwardly rectifying [K.sup.+] channels (GIRK) channels in these interneurons.
(8) Harriet Jacobs, Jean Yeilin Fagin, and Lydia Maria Childs, editors, Incidents in the Life of a Slave Girk Written by Herself (Boston: Harvard University Press), 1987.
(96.) [ARABIC TEXT NOT REPRODUCIBLE IN ASCII] [A [A Narration concerning the Dormition of the Theotokos and Ever-Virgin Mary by the Blessed Nicodemus]," in [ARABIC TEXT NOT REPRODUCIBLE IN ASCII] [Ankanon Girk' Nor Ktakaranac'], [ARABIC TEXT NOT REPRODUCIBLE IN ASCII] [T'angaran Haykakan Hin ew Nor Dprut'eanc' 2] (Venice: I Dparani S.
44, the first text entitled Girk' Eakac' is a valuable narrative which has little to do with the Girk' Eakac' quoted on p.
In smooth muscles cells the [G.sub.q]-coupled hM3 DREADD receptor stimulated a cascade of inositol phosphate hydrolysis, calcium release and ERK1/2 activation, while the hM4Di DREADD receptor, derived from the [G.sub.i]-coupled human muscarinic M4 receptor, inhibited forskolin-induced cAMP formation and activation of GIRK causing hyperpolarization and inhibition of neuronal firing [54].
GIRK channels primarily mediate the inhibitory effects of certain G-protein--coupled neurotransmitter receptors (Luscher et al.
In their previous research, Slesinger's team focused on the neural function of these ion channels, called GIRK channels, which open up during periods of chemical communication between neurons and dampen the signal, creating the equivalent of a short circuit.