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Oocyte quality and endometrial receptivity factors have important roles in the implantation process.1,2 It has been reported in many studies and meta-analyses that luteal phase defect (LPD) is encountered following the controlled ovarian hyperstimulation (COH) in both the GnRH agonist and antagonist protocols, and that luteal phase support (LPS) should routinely be administered in these cycles in order to increase the implantation rates.3-7 However, many subjects including the most proper agent, the timing to start, duration and route of administration are still controversial although the requirement of LPS is proven.7-12
The study included primary or secondary infertile women with major indications for IVF and who were treated with either conventional agonist long protocol or the GnRH antagonist fixed protocol.
The levels of cortisol, ERs, and VTG increased in FW (Figure 5), supporting the findings of previous studies (Rayner and Trayhum, 2001; Nagasaka et al., 2006) that showed that increased concentrations of estrogen and cortisol directly increase leptin, are involved in appetite, energy balance, and growth, and accelerate the secretion of GnRH to induce sexual maturation.
GnRHs aren't a cure for prostate cancer--tumors can eventually become resistant--but can prolong survival, and as such they play a vital role in treating the disease.
The Food and Drug Administration (FDA) has announced that it is investigating the safety of gonadotropin-releasing hormone (GnRH) agonists, a class of drugs used to treat prostate cancer, after evidence linking them with a rise in the risk of heart disease and diabetes.
Lupron is a Gonadotropin-Releasing Hormone Analog Agonist (GnRH); these drugs shut down the pituitary gland, thereby reducing the amount of testosterone produced by men, and estrogen produced by women: For women, this causes the rapid and artificial onset of menopause potentially with incapacitating and long-lasting effects.
So, Zohar, who was then at the Israeli National Center for Mariculture in Eilat, and his colleagues developed scores of synthetic GnRHs that could resist breakdown.
However, gonadotropin-releasing hormone (GnRH) plays a pivotal role in the regulation of reproduction in vertebrates through interaction with a specific receptor.
Despite these observations, only recently has the mechanism involving direct/indirect endocannabinoid activity on the hypothalamic GnRH secreting neurons been provided.
GnRH immunorcactive neuronal system in the presumptive ancestral chordate, Ciona intestinalis (Ascidian).