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In both cases transcription of gnt genes is repressed by GntR, a protein that served as a prototype for the entire GntR family of regulators.
GntR type transcriptional factors act as repressors of gene transcription.
Most GntR regulators either repress or activate the transcription of their own genes.
Typically, genes responsible for gluconate uptake are organized into an operon under negative control of the GntR repressor [25] (see Figure 1).
Protein Sco1678, encoded within Streptomyces coelicolor M145 genome, belongs to twelve of the most conserved regulators of GntR family across class of Actinobacteria.
Zaburannyi et al., "Transcriptional regulators of GntR family in Streptomyces coelicolor A3(2): analysis in silico and in vivo of YtrA subfamily," Folia Microbiologica, vol.
Conway, "Cloning and molecular genetic characterization of the Escherichia coli gntR, gntK, and gntU genes of GntI, the main system for gluconate metabolism," Journal of Bacteriology, vol.
Rigali, "Variation in form and function the helix-turn-helix regulators of the GntR superfamily," in Advances in Applied Microbiology, vol.
Salmond, "A GntR family transcriptional regulator (PigT) controls gluconate-mediated repression and defines a new, independent pathway for regulation of the tripyrrole antibiotic, prodigiosin, in Serratia," Microbiology, vol.