Kim et al., "Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis," Journal ofLipid Research, vol.
AGPAT: 1- acyl-sn-glycerol-3-phosphate acyltransferase; DG: diacylglycerol; DGAT: diacylglycerol o-acyltransferases; G3P: glycerol-3-phosphate; GPAT: glycerol- 3phosphate acyltransferase; LPA: lysophosphatidic acid; PA: phosphatidic acid; PPAR[gamma]: peroxisome proliferator-activated receptor gamma; TG: triacylglycerol.
Conservation of catalytic residues suggested that LpxL is related to the glycerol-3-phosphate acyltransferase (GPAT
) family .
ACC: acetyl-CoA carboxylase; ACL: ATP-citrate lyase; AGPAT: 1-acylglycerol-3-phosphate acyltransferase; aP2: fatty acid binding protein; DGAT: diacylglycerol acyltransferase; ME: malic enzyme; FAS: fatty acid synthase; GPAT
: glycerol-3-phosphate acyltransferase; GPDH: glycerol phosphate dehydrogenase; LPL: lipoprotein lipase; MDH: malate dehydrogenase; OAA: oxaloacetate; PC: piruvate carboxylase; PDH; piruvate dehydrogenase; PEPCK: phosphoenolpyruvate carboxykinase; VLDL: very low-density lipoprotein.
The storm cells had winds gusting to around 85km/h and localised heavy rainfall, while more than 3500 lightning strikes were recorded on the GPATs
Once formed, FA-CoA is used for the first acylation of glycerol-3-phosphate via glycerol-3-phosphate acyltransferase (GPAT
) enzymes, which produces 1-acylglycerol-3-phosphate (MAG-P) (Figure 2).