GPMBPGuinea Pig Myelin Basic Protein
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Complete Freund's adjuvant containing 10mg/ml heat-killed Mycobacterium tuberculosis H37RA (Difco) in Incomplete Freund's adjuvant (Imject; Thermo Scientific) was mixed 1 : 1 with a 1 mg/ml solution of guinea pig myelin basic protein (gpMBP, Sigma USA, or extracted from guinea pig spinal cord) in PBS and mechanically emulsified for 10 minutes (Norm-Ject luer lock; cat.
Lewis rats immunized with gpMBP to induce EAE and then injected with pooled IgG from AQP4-seropositive patients developed AQP4-depleted lesions in the spinal cord.
Caption: Figure 1: (a, b) After immunizing Lewis rats with gpMBP to induce EAE, CXCR2 antagonist (red triangles) or vehicle control (green circles) was injected at the time points indicated by the black arrows and pooled IgG from AQP4-seropositive NMO patients was injected at the time points indicated by the pink arrows.