GRIK1Glutamate Receptor Ionotropic Kainate 1
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Topiramate treatment for heavy drinkers: Moderation by a GRIK1 polymorphism.
Patients were genotyped for the single nucleotide polymorphism (rs2832407) in GRIK1 (glutamate receptor, ionotropic, kainate 1), a large gene on chromosome 21, which "encodes the Gluk1 subunit of the kainate (glutamate) receptor" to evaluate its impact as a moderator of topiramate's effects on drinking and on the adverse effects of the drug.
GRIK1 Genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink.