GRMDGender Rights Maryland (Laurel, MD)
GRMDGolden Retriever Muscular Dystrophy
GRMDGerencia Recursos Mineros y Desarrollo (Chilean Mining Companies)
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References in periodicals archive ?
GRMD is similar to DMD in humans due to clinical and pathological characteristics, in which young adult dogs often die from respiratory or cardiac failure (VALENTINE et al., 1988).
This review presents an overview of DMD and the pathological, immunological and molecular studies that have involved the GRMD model, highlighting its contribution to a better understanding pathophysiology and morphofunctional expression of the disease.
GRMD is characterized by progressive muscle weakness and atrophy.
The canine GRMD model is undoubtedly the closest to the human disease, presenting severe cardiac and skeletal alterations similar to those observed in those affected by DMD.
Bortezomib (PS-341) treatment decreases inflammation and partially rescues the expression of the dystrophinglycoprotein complex in GRMD dogs.
Effects of an immunosuppressive treatment in the GRMD dog model of Duchenne muscular dystrophy.
Influencia do bloqueador de receptor de angiotensina (Losartana potassica) na funcao renal e pressao arterial em caes GRMD. Pesquisa Veterinaria Brasileira, v.29, p.322-326, 2009.
TGF-[beta]1 mRNA levels are significantly higher in 30-day-old GRMD than in healthy dogs.
Abbreviations BMD: Becker muscular dystrophy CCL: Beta-chemokine CXCL: Alpha-chemokine DMD: Duchenne muscular dystrophy GRMD: Golden retriever muscular dystrophy HFMD: Hypertrophic feline muscular dystrophy IIM: Idiopathic inflammatory myopathies IFN: Interferon IL: Interleukin TGF: Transforming growth factor TNF: Tumor necrosis factor.
O pancreas foi visibilizado em cinco dos 24 caes GRMD estudados, identificando-se a veia pancreaticoduodenal e o ducto pancreatico (Figura 3A e B).
Tabela 1 - Porcentagens dos achados ultra-sonograficos em figado, vesicula biliar, bexiga urinaria, glandula adrenal, pancreas e baco nos animais sadios, afetados e portadores de distrofia muscular do labrador retriever (GRMD) Achados Caes Caes ultra-sonograficos Caes sadios afetados portadores Figado Hepatomegalia 75% 100% 44,4% Textura hiperecoica 87,5% 83,3% 88, 8% Vesicula biliar Lama biliar 0% 50% 0% Colelitiase 0% 16, 6% 0% Pontos hiperecoicos 0% 0% 11,1% Vesicula urinaria Pontos hiperecoicos 0% 50% 0% Glandula adrenal Aumento de volume 0% 16,6% 0% Pancreas Visualizacao NV (a) 83,3% NV (a) Baco Pontos hiperecoicos 0% 16,6% 0% no parequima (NV a) Nao visualizado.