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GRP-94Glucose-Regulated Protein 78kD and 94kD
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Treatment of BFP also increased a number of signature endoplasmic reticulum (ER) stress markers glucose-regulated protein (GRP)-78, GRP-94, IRE1, phosphorylation of eukaryotic initiation factor-2[alpha] (eIF-2[alpha]) and up-regulation of CAATienhancer-binding protein homologous protein (CHOP).
The UPR induces the expression of ER-resident chaperones, such as GRP(glucose-regulated protein)-78 and GRP-94 (Lee 2001).